Coronavirus: Astra’s investigation discovered that none of the trial’s participants who took the cocktail got severe Covid-19 or died as a result of the disease.
Astra stated in a statement Friday that no one in the experiment who got the combination acquired severe Covid-19 or died as a result of the condition. The study enrolled 5,197 individuals and began in November. It examined whether the medication might prevent infection in at-risk populations. It was conducted in the United States, the United Kingdom, Belgium, France, and Spain.
The findings will come as a comfort to Astra following the failure of another research in June evaluating whether the cocktail could prevent symptomatic Covid-19 infection in patients who had been directly exposed to the virus. Additionally, the discoveries may help rescue a contract with the United States to acquire the medication. The US had placed an order for up to 700,000 doses for delivery in 2021, the value of which was contingent on the trial’s failure.
Astra stated in June that it was in “ongoing” negotiations with the US government and was awaiting the findings of this current research, dubbed Provent, before making a decision. For the primary analysis, the trial enrolled 25 patients with symptomatic Covid-19 infections. The AZD7442 cocktail was administered to volunteers in a 2:1 randomized drug-to-placebo ratio.
“We require alternative ways to safeguard those who do not receive enough protection with Covid-19 vaccinations,” Mene Pangalos, executive vice president of biopharmaceuticals research and development, said in a statement. “These effectiveness and safety findings in high-risk individuals provide us with great hope.”
The business stated that it was compiling the data for submission to regulators in preparation for possible emergency-use authorization.
Antibody medicines are considered as a means to possibly protect those who do not respond well to vaccination, such as cancer patients, however, the products are difficult to administer and scale-up is restricted. Trials evaluating both preventive and treatment strategies for Covid-19 have had varying degrees of effectiveness. GlaxoSmithKline Plc and Vir Biotechnology Inc. gained emergency-use permission in the United States in May after demonstrating that their medication may prevent at-risk patients from deteriorating, despite the failure of an earlier trial in hospitalized patients.
On Friday, the United Kingdom authorized its first monoclonal antibody therapy for Covid-19, approving a medication developed by Regeneron Pharmaceuticals Inc. and Roche Holding AG.